Medicines for depression

Depression is a mental illness that makes a person feel sad or unable to enjoy anything for weeks at a time. Depression can stop people being able to do their job, study, or look after themselves and their family. It can be a short-term illness, or it can come and go throughout a person’s life.

Depression can have many causes, including genes, stress and life problems, health problems, unhealthy eating, not sleeping well, using alcohol or other drugs, and some medications. With the right treatment, someone with depression can recover and live a full, satisfying life.

Symptoms of depression may include:

  1. Little interest or pleasure in doing things
  2. Feeling down, depressed, or hopeless
  3. Trouble falling or staying asleep, or sleeping too much
  4. Feeling tired or having little energy
  5. Poor appetite or overeating
  6. Feeling bad about yourself—or that you are a failure or have let yourself or your family down
  7. Trouble concentrating on things, such as reading the newspaper or watching television 8. Moving or speaking so slowly that other people could have noticed. Or the opposite—being so fidgety or restless that you have been moving around a lot more than usual
  8. Thoughts that you would be better off dead, or of hurting yourself in some way

Depression treatment

Antidepressant

The effectiveness of antidepressant medications is generally comparable between and within classes of medications, including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), bupropion, tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). Therefore, choose a medication largely based on the following:

  • Patient preference
  • Nature of prior response to medication
  • Safety, tolerability, and anticipated side effects
  • Co-occurring psychiatric or general medical conditions
  • Pharmacological properties of the medication (e.g., halflife, actions on cytochrome P450 enzymes, other drug interactions; consult the full guideline or a current drug database)
  • Cost

The selective serotonin reuptake inhibitors (SSRIs), SNRIs, agomelatine, bupropion, and mirtazapine remain the best option for major depressive disorder. Vortioxetine is also a first-line recommendation.

Recommended second-line agents include TCAs, quetiapine and trazodone (owing to higher side effect burden), moclobemide and selegiline (potential serious drug interactions), levomilnacipran (lack of comparative and relapse-prevention data), and vilazodone (lack of comparative and relapse prevention data and the need to titrate and take with food).

A third option may be MAO inhibitors, these however may lead to higher side effects and potential serious drug and dietary interactions or you can opt for reboxetine which is known for its low efficiency wilowerefficacy).

Psychological treatments

Psychological treatments (talking therapies) are used to treat all types of depression. For mild depression they might be the only treatment needed.

Treatment is provided by trained therapists (e.g. psychiatrists, psychologists, or GPs).

Several different psychological treatments work for depression. These include:

  • cognitive behavioural therapy (CBT)
  • interpersonal psychotherapy
  • problem-solving therapy
  • short-term psychodynamic therapy.

 

CBT and interpersonal therapy work just as well as medication for people with mild-to-moderate depression.

For psychological treatment to work well, you need a good working relationship with your doctor or other therapist. You need to be able to trust them and stay hopeful about your recovery.

CBD oil for Depression

CBD Vape oil has become widely recognised as a natural health supplement, and news about its extraordinary healing abilities has spread like wildfire around the internet.

Cannabidiol(CBD)is a chemical compound that comes from the hemp plant. It is one of over 85 unique compounds found in hemp, known as cannabinoids. While its exact benefits and effects are still being researched, it is interesting to note that the United States Department of Health and Human Services holds a patent titled ‘Cannabinoids as Antioxidants and Neuroprotectants’, which claims that:

Cannabinoids, which can be either consumed (phytocannabinoids) or produced naturally by the body (endocannabinoid), are chemical compounds that interact with the body’s central regulatory system (the endocannabinoid system). This system is known to manage homeostasis and affect bodily processes such as appetite, mood and sleep.

What about depression – how does CBD oil work in alleviating it? Well, CBD Vape oil works in one major way – it stimulates the parasympathetic nervous system (which is the part of your nervous system responsible for promoting rest, healing, rejuvenating and regenerating) and it inhibits the effects of the sympathetic nervous system (which is responsible for eliciting stressful responses, both physical, psychological and emotional, as well as triggering the fight-or-flight mechanism).

Some scientists claim that depression is an adaptive physical and psychological behavior due to excessive exposure to stress (which, again, can be physical, psychological or emotional). So it reasons to say that if you reduce the stress load which your body is dealing with then the depression will also be alleviated – right?

Turns out that this logic is sound and works. Numerous studies have been published recently (such as in this NCIB study) which shows that CBD oil is not only very effective in treating depression (showing great further promise in developing pharmaceutical drugs based on it) but it is also very effective in treating other psychiatric disorders such as anxiety, schizophrenia as well as other mood disorders.